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Zylet® Eye Drops (Anti-inflammatory/Antibacterial)


Key Features & Benefits

  • Efficacious against inflammatory eye conditions with risk of infection.1,2
  • A combination formulation containing Corticosteroid & Antibiotic.1,2,4

How often should you use?


Apply one or two drops of Zylet into the conjunctival sac of the affected eye(s) every four to six hours. During the initial 24 to 48 hours, the dosing may be increased, to every one to two hours. Frequency should be decreased gradually as warranted by improvement in clinical signs. Care should be taken not to discontinue therapy prematurely. Not more than 20ml should be prescribed initially and the prescription should not be refilled without further evaluation by a physician.


Loteprednol Etabonate 5mg/ml (0.5%) and Tobramycin 3 mg/ml (0.3%), Edetate Disodium, Glycerin, Povidone, Purified Water, Tyloxapol, and Benzalkonium Chloride 0.01% (preservative). Sulfuric Acid and/or Sodium Hydroxide may be added to adjust the pH.


ZYLET® is supplied in a white low density polyethylene plastic bottle with a white controlled drop tip and a white polypropylene cap in the 5mL bottle.

Important information about using Zylet® Eye Drops 0.5%/0.3% (Anti-inflammation/ Antibiotics)

Note: Please consult a doctor prior to using this product.

General: For ophthalmic use only. The initial prescription and renewal of the medication order beyond 14 days should be made by a physician only after examination of the patient with the aid of magnification, such as slit lamp biomicroscopy and, where appropriate, fluorescein staining. If signs and symptoms fail to improve after 2 days, the patient should be re-evaluated.

If this product is used for 10 days or longer, intraocular pressure should be monitored even though it may be difficult in children and uncooperative patients.

Fungal infections of the cornea are particularly prone to develop coincidentally with long-term local steroid application. Fungus invasion must be considered in any persistent corneal ulceration where a steroid has been used or is in use. Fungal cultures should be taken when appropriate.

As with other antibiotic preparations, prolonged use may result in overgrowth of nonsusceptible organisms, including fungi. If superinfection occurs, appropriate therapy should be initiated.

Cross-sensitivity to other aminoglycoside antibiotics may occur; if hypersensitivity develops with this product, discontinue use and institute appropriate therapy.

This product is sterile when packaged. Please be advised that the dropper tip should not touch any surface, as this may contaminate the suspension. If pain develops, redness, itching or inflammation becomes aggravated, please consult a physician. This preparation contains benzalkonium chloride as preservative, do not to wear soft contact lenses when using Zylet.

Full product information is available on request from Bausch + Lomb Singapore.


1. ZYLET® full prescribing information (Singapore).

2. White EM, Macy JI, Bateman KM, Comstock TL. Comparison of the safety and efficacy of loteprednol 0.5%/tobramycin 0.3% with dexamethasone 0.1%/tobramycin 0.3% in the treatment of blepharokeratoconjunctivitis. Curr Med Res Opin. 2008;24(1):287-296.

3. Holland EJ, Bartlett JD, Paterno MR, Usner DW, Comstock TL. Effects of loteprednol/tobramycin versus dexamethasone/tobramycin on intraocular pressure in healthy volunteers. Cornea. 2008;27(1):50-55.

4. Guillon M, Maissa C, Pouliquen P, Delval L. Effect of povidone 2% preservative-free eye drops on contact lens wearers with computer visual syndrome: pilot study. Eye Contact Lens. 2004;30(1):34-39.